Records show the smallpox epidemic of 1721 was a sickness which swept through the city of Boston, in the United States, it killed hundreds at a time even before modern medical treatment or a robust understanding of infectious disease was possible. An enslaved man known only as Onesimus (On-esi-mus) suggested a potential way to keep people from getting sick. Intrigued by Onesimus’ idea, a brave doctor and an outspoken minister undertook a bold experiment to try to stop smallpox in its tracks.
From records and logs we see Smallpox entered the colonies on slave ships, transmitted by enslaved people who, in packed and unsanitary quarters given to them from the white man, passed the disease along to one another and, eventually, to colonists at their destinations. One of those destinations was Massachusetts, which was a centre of the early slave trade. The first slaves had arrived in Massachusetts in 1638.
In 1706, an enslaved West African man was purchased for the prominent Puritan minister Cotton Mather by his congregation. Mather gave the West African Man the name Onesimus (On-esi-mus) after a Biblical slave whose name meant “useful.” Mather, who had been a powerful figure in slave ownership took a duty to convert slaves to Christianity and educate them. It was in 1716, Onesimus told him something he did believe: That he knew how to prevent smallpox.
Onesimus, who “is a pretty intelligent fellow,” Mather wrote, told him he had had smallpox—and then hadn’t. Onesimus said that he had undergone an operation, which had given him something of the smallpox and would forever preserve him from it...and whoever had the courage to use it was forever free of the fear of contagion.
The operation Onesimus referred to consisted of rubbing pus from an infected person into an open wound on the arm. Once the infected material was introduced into the body, the person who underwent the procedure was inoculated against smallpox. It wasn’t a vaccination, which involves exposure to a less dangerous virus to provoke immunity. But it did activate the recipient’s immune response and protected against the disease most of the time. Mather was fascinated. He verified Onesimus’ story with that of other enslaved people, and learned that the practice had been used from Turkey all the way to China.
In 1721, Mather and Zabdiel Boylston, the only physician in Boston who supported the technique, got their chance to test the power of inoculation. That year, a smallpox epidemic spread from a ship to the population of Boston, sickening about half of the city’s residents. Boylston sprang into action, inoculating his Son and his slaves against the disease. Then, he began inoculating other Bostonians. Of the 242 people he inoculated, only six died—one in 40, as opposed to one in seven deaths among the population of Boston who didn’t undergo the procedure.
Its not clear if Onesimus lived to see the success of the technique he introduced to Mather? Nothing is known of his later life other than that he partially purchased his freedom. What is clear is that the knowledge he passed on saved thausands of lives—and led to the eventual eradication of smallpox. From 1716 to 1980, and the World Health Organisation declared smallpox entirely eradicated due to the spread of immunisation worldwide. It remains the only infectious disease to have been entirely wiped out.
The question begs, how did Onesimus know this worked? We can only guess that he was educated from his family and the culture he was surounded by back in Africa. - Does anyone know this story, or what happened to Onesimus or even his real name? Do you know any other facinating stories which may also be lost in time? Pop a comment below.
So it’s with thanks to Onesimus, we speed up to present day....
Did you know that scientists have been working on over 70 types of COVID vaccines? There are two main types likely to be rolled out above all others.
Let’s look at the first one, the classical vaccine...
Backed by AstraZeneca and Oxford. This vaccine - called ChAdOx1 nCoV-19 - uses a harmless, weakened version of a common virus which currently only causes a cold in chimpanzees. Researchers have already used this technology to produce vaccines against a number of pathogens including flu, Zika and Middle East respiratory syndrome (Mers). The virus is genetically modified so it is impossible for it to grow in humans. Known as classical vaccines.
Scientists have transferred the genetic instructions for coronavirus's specific "spike protein" - which it needs to invade cells - to the vaccine. When the vaccine enters cells inside the body, it uses this genetic code to produce the surface spike protein of the coronavirus. This induces an immune response, priming the immune system to attack coronavirus if it infects the body.
So lets look at the second type of vaccine....The new technogy which actually began in the 1950's...
Backed by PFizer, BioNTech and Moderna. These jabs are messenger vaccines or (mRNA) vaccines. Its actually like putting the drug factory inside you, unlike the classical vaccine. in other terms it’s like a computer downloading software. The vaccine is the software being installed into your body, your body being the computer.
mRNA vaccines, in contrast to classical vaccines trick the body into producing some of the viral proteins itself. They work by using mRNA, or messenger RNA, which is the molecule that essentially puts DNA instructions into action. Inside a cell, mRNA is used as a template to build a protein. ‘An mRNA is basically like a pre-form of a protein and its what the protein is basically made of later on.
To produce an mRNA vaccine, scientists produce a synthetic version of the mRNA that a virus uses to build its infectious proteins. This mRNA is delivered into the human body, whose cells read it as instructions to build that viral protein, and therefore create some of the virus’s molecules themselves. These proteins are solitary, so they dont assemble to form a virus. The immune system then detects these viral proteins and starts to produce a defensive response to them.
The Pfizer, AstraZeneca and Moderna vaccines have been shown to provoke both an antibody and T-cell response. Antibodies are proteins that bind to the body's foreign invaders and tell the immune system it needs to take action. T-cells are a type of white blood cell which hunt down infected cells in the body and destroy them.
Nearly all effective vaccines induce both responses. Moderna vaccine may have an edge: Unlike Pfizer’s and BioNTech’s offering, it does not have to be stored at –70°C, but can tolerate a much warmer –20°C, which is standard for most hospital and pharmacy freezers. That difference means Moderna’s vaccine should be easier to distribute and store. The Oxford vaccine induces robust antibody and T-cell responses across people of all ages, so the data indicates. But on the news were not really told much about the differences, but why?
It all sounds fascinating and high tech but the idea of mRNA was born in the 1950’s. The actual acceptance of the genetic role of DNA only began in 1944. A key insight came in 1953 for when it was suggested that the sequence of bases on a DNA molecule contains ‘genetical information’. This involved proteins being synthesised on the DNA molecule itself. The issue then became how that information was turned into a biological function — to then suggesting a model for how the genetic code might function, This is what we would now identify as mRNA.
Let’s not jump for joy just yet...
In contrast, Robert Francis Kennedy Jr. who is an American environmental lawyer, son of Robert F. Kennedy and nephew of former president John F. Kennedy has brought some very interesting reading to the narrative and rhetoric.
Robert Francis Kennedy Jr has researched...For the first time in the history of vaccination, the so-called last generation mRNA vaccines intervene directly in the genetic material of the patient and therefore alter the individual genetic material, which represents the genetic manipulation, something that was already forbidden and until then considered criminal. This intervention can be compared to genetically manipulated food, which is also highly controversial.
Even if the media and politicians currently trivialise the problem and even stupidly call for a new type of vaccine to return to normality, this vaccination is problematic in terms of health, morality and ethics, and also in terms of genetic damage that, unlike the damage caused by previous vaccines, will be irreversible and irreparable.
after an unprecedented mRNA vaccine, you will no longer be able to treat the vaccine symptoms in a complementary way. They will have to live with the consequences, because they can no longer be cured simply by removing toxins from the human body, just as a person with a genetic defect like Down syndrome, Klinefelter syndrome, Turner syndrome, genetic cardiac arrest, hemophilia, cystic fibrosis, Rett syndrome, etc.), because the genetic defect is forever!
This means clearly: if a vaccination symptom develops after an mRNA vaccination, no lawyer, doctor or therapist can help you, because the damage caused by the vaccination will be genetically irreversible. He says these new vaccines represent a crime against humanity that has never been committed in such a big way in history. As Dr. Wolfgang Wodarg, an experienced doctor, said: In fact, this "promising vaccine" for the vast majority of people should be FORBIDDEN, because it is genetic manipulation! "
The vaccine, developed and endorsed by Anthony Fauci and funded by Bill Gates, uses experimental mRNA technology. Note: Three human guinea pigs have already experienced a "serious adverse event". Note: messenger RNA or mRNA is the acid that transfers the genetic code of the DNA. It basically determines the order in which the amino acids of a protein bind and act as a mold or pattern for the synthesis of that protein.
So now Robert Francis Kennedy Jr answered these ‘not so’ FAQ:-
Troubling safety problems with its most ambitious therapy
I've unlearned Moderna Therapeutics are the most highly valued private company in biotech, they have actually run into troubling safety problems with its most ambitious therapy — and is now banking on a mysterious new technology to keep afloat its brash promise of reinventing modern medicine. I wonder if this is mRNA? A few years back, Moderna CEO Stéphane Bancel talked up his company’s “unbelievable” future before a standing-room-only crowd at the annual J.P. Morgan Healthcare Conference. He promised that Moderna’s treatment for a rare disease known as Crigler-Najjar syndrome, developed alongside biotech giant Alexion Pharmaceuticals, would enter human trials by 2016.
It was to be the first therapy using audacious new technology that Bancel promised would yield dozens of drugs in the coming decade. But the Crigler-Najjar treatment has been indefinitely delayed, an Alexion spokeswoman mentioned. It never proved safe enough to test in humans, according to several former Moderna employees and collaborators who worked closely on the project. Unable to press forward with that technology, Moderna has had to focus instead on developing a handful of vaccines, turning to a less lucrative field that might not justify the company’s nearly $5 billion valuation.
“It’s all vaccines right now, and vaccines are a loss-leader,” said one former Moderna manager. “Moderna right now is a multibillion-dollar vaccines company, and I don’t see how that holds up.”
Bancel made no mention of the Crigler-Najjar drug when he spoke previously to this at a similarly packed room at a J.P. Morgan conference.
His presentation instead focused on four vaccines that the company is moving through the first phase of clinical trials: two target strains of influenza, a third is for Zika virus, and the fourth remains a secret. Bancel clicked through graphs of data from animal studies before hurrying on to tout Moderna’s balance sheet and discuss the company’s cancer vaccines, slated for clinical testing by the way.
Only Founded in 2012, Moderna reached unicorn status — a $1 billion valuation — in just two years, faster than Uber, Dropbox, and Lyft. The company’s premise: Using custom-built strands of messenger RNA, known as mRNA, it aims to turn the body’s cells into ad hoc drug factories, compelling them to produce the proteins needed to treat a wide variety of diseases. Just as we have all unlearned so far.
But mRNA is a tricky technology. Several major pharmaceutical companies have tried and abandoned the idea, struggling to get mRNA into cells without triggering nasty side effects.
Bancel has repeatedly promised that Moderna’s new therapies will change the world, but the company has refused to publish any data on its mRNA vehicles, sparking skepticism from some scientists. The indefinite delay on the Crigler-Najjar project signals persistent and troubling safety concerns for any mRNA treatment that needs to be delivered in multiple doses, covering almost everything that isn’t a vaccine, former employees and collaborators said.
The company did disclose a new technology that it says will more safely deliver mRNA. It’s called V1GL. Bancel told Forbes about another new technology, N1GL. But in neither case has the company provided any details. And that lack of specificity has inevitably raised questions.
Three former employees and collaborators close to the process said Moderna was always toiling away on new delivery technologies in hopes of hitting on something safer than what it had. (Even Bancel has acknowledged, in an interview with Forbes, that the delivery method used in Moderna’s first vaccines “was not very good.”)
In order to protect mRNA molecules from the body’s natural defenses, drug developers must wrap them in a protective casing. For Moderna, that meant putting its Crigler-Najjar therapy in nanoparticles made of lipids. And for its chemists, those nanoparticles created a daunting challenge: Dose too little, and you don’t get enough enzyme to affect the disease; dose too much, and the drug is too toxic for patients.
From the start, Moderna’s scientists knew that using mRNA to spur protein production would be a tough task, so they scoured the medical literature for diseases that might be treated with just small amounts of additional protein.
“And that list of diseases is very, very short,” said the former employee who described Bancel as needing a Hail Mary. Is COVID this Hail Mary? Crigler-Najjar was the lowest-hanging fruit. Yet Moderna could not make its therapy work, former employees and collaborators said. The safe dose was too weak, and repeat injections of a dose strong enough to be effective had troubling effects on the liver in animal studies.
So let’s take a breather, and summarise. We have new gene therapy ‘so called’ almost ready to roll out to millions and which we still have have yet to fathom out the long term irreversible side-affects to humans from the 1950’s. We have a classical vaccine almost available to the public months after the panademic started, when classical vaccines take about 10 years to develop. We have one of the largest pharmaceutical companies in the world a front runner in the supply to major government’s around the world, they’ve openly been designing influenza vaccines for years plus a secret vaccine, and seemingly only interested their profits over side-effects. Funded by Bill Gates who himself hosted an edition of TedTalks a few years back (Link on my previous blog ‘COVID the Sheepdog’) about how the next virus to hit the world would be the deadliest and how the world is not set up to stop it.
What are these pharmaceutical companies deeming to be the definition of safe? Is it worth taking at all, given the risks on all sides and that the virus has a 99.5% recovery rate? There are many questions to ask right now. I really don’t blame anyone for taking the vaccine given the narrative and rhetoric our Media is subjecting citizens too. But at least do your own research first and be content with it. For example, ask all the possible questions to the trained medical person who is vaccinating you and your family. If your not happy with the answers don’t have it. Ask about the transportation, the storage of the vaccine, What’s the correct dose? Will I need more than one vaccine? what side-effects will there be? Is the person vaccinating me and my family fully trained? Does my children need a different dose? Get a signed document to these as there’s no u-turn on contamination or incorrect information. Don’t get the vaccine yourself or your family if none of these questions are answered.
Meanwhile...We continue to read and listen to what we can from our Media. I hope all this unlearning has provided some food for thought, maybe provoked you to comment on anything i've mentioned today. I look forward to unlearning more on WARoftheWORDS.
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